Nucleophosmin 1
NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its … Meer weergeven Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. Meer weergeven NPM1 gene is up-regulated, mutated and chromosomally translocated in many tumor types. Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, … Meer weergeven • Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, Wilkinson KD, Dasso M (November 2008). "Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases" Meer weergeven NPM1 has been shown to interact with • AKT1, • BARD1, • BRCA1, and • nucleolin. Nucleophosmin has multiple binding partners: Meer weergeven Web22 aug. 2024 · Go to Brief Summary: Phase 1 dose escalation will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of SNDX-5613 in …
Nucleophosmin 1
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Web27 mei 2024 · 1. Introduction. AML is a malignancy characterized by clonal proliferation originating from primitive hematopoietic stem or progenitor cells. According to the 2016 … Webnucleophosmin 1 Normal Function The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the …
WebNucleophosmin 1 (NPM1) is a driver gene that is mutated in 30%–35% of AMLs (3, 6). Although AMLs are often heterogeneous mixtures of different leukemic subclones ( 3 , 7 … WebNPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, …
http://www.als-journal.com/10114-23/ WebNucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations. haematologica, …
Web21 nov. 2014 · Nucleophosmin 1 (NPM1, also referred to as B23 or numatrin in mammals, and NO38 in amphibians) is a ubiquitously expressed nucleolar phosphoprotein and is a …
WebBy Western blot, this antibody detects an ∽ 38 kDa protein corresponding to human, mouse, and rat nucleophosmin in various cell lysates. The PA1-029 immunogen is a … famous footwear boots womenWebStimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a … famous footwear boots for womenWeb24 aug. 2016 · Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin … coping with erectile dysfunction michael metzWebKeywords: AML, DNA methyltransferases 3A, nucleophosmin 1, next-generation sequencing, prognosis Introduction Acute myeloid leukemia (AML) is a kind of … coping with epilepsy forumWebWe demonstrate a requirement for nucleophosmin (NPM, B23.1) in this apoptotic effect, and the apoptotic effect of stress-induced nucleolar RelA. We show by multiple … famous footwear boots women-fleece linedWebInteractions of the Natural Product (+)-Avrainvillamide with Nucleophosmin and Exportin-1 Mediate the Cellular Localization of Nucleophosmin and its AML-Associated Mutants ... famous footwear boots menWebNPM1, nucleophosmin 1 Vertebrate Orthologs 4 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog NPM1, nucleophosmin 1. Synonyms B23, NPM Links HGNC:7910. NCBI Gene ID: 4869. neXtProt AC: NX_P06748. UniProt ... famous footwear boots girls